A few days ago, Russian Science and Technology (NUST-M) published a research result in the ACS Journal of Applied Materials and Interface. They developed an antibacterial nano coating based on boron nitride, which has high efficacy against microbial pathogens (99.99%). , And no obvious side effects, it can be used to replace antibiotics in implant surgery. Boron oxide

Surgery, especially orthopedics and dental surgery, implants are likely to introduce microorganisms and cause infections. Antibiotics are a problem, but high doses of antibiotics can bring side effects. The NUST-M researchers passed that the boron nitride nano-film coating killed Gram-negative bacteria and E. coli within 24 hours. "Hexagonal boron nitride has physical, chemical and mechanical properties. The experimental results show that the structure of boron nitride nanoparticles provides a bactericidal effect equivalent to antibiotics: bacterial death is due to direct physical contact with the needle-like surface of the nano film. ”Explained Christina Gudz, a researcher at the Inorganic Nanomaterials Laboratory.

The researchers further filled the micropores with a thin layer of boron nitride coating with gentamicin antibiotics. Since the drug is completely released in a short time, it produces an antibacterial effect. Moreover, its dose is an order of magnitude smaller than conventional injections. "Considering that the patient’s average weight is 60 kg, his daily antibiotic dose is about 180 mg; assuming that the implantation area is 30 square centimeters, and considering that the nano coating in the study releases 55 micrograms of antibiotics per day, the results show The proposed method assumes that antibiotics are 100 times less "injected" than standard drugs," Christina Gudz added.

At present, the team is completing in vitro research on the obtained coating and is optimizing the coating method in order to achieve practical applications in the future.